Gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease.

A new study published in the Quality of Life Research investigated the mediating effects of patient-perceived medication adherence barriers in the relationship between gastrointestinal symptoms and generic health-related quality of life (HRQOL) in adolescents with inflammatory bowel disease (IBD). Here, the Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms, Medicines, Communication, Gastrointestinal Worry, and Generic Core Scales were completed in a 9-site study by 172 adolescents with IBD. It was observed that, demographic variables, gastrointestinal symptoms (stomach pain, constipation, or diarrhea), and perceived medication adherence barriers significantly accounted for 45, 38, and 29 percent of the variance in HRQOL, respectively, demonstrating large effect sizes. From the results, it was stated that perceived medication adherence barriers explain in part the effects of gastrointestinal symptoms on HRQOL in adolescents with IBD. It was stated that patient health communication to healthcare providers further explain the relationship between gastrointestinal symptoms, perceived medication adherence barriers, and HRQOL.1

Reference1. JW V, RJ S, MM S et al. Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease. Quality of Life Research. 2017.