Gender-Based Differences in a Population-Based Cohort with Celiac Disease.

The goal of a new article published in Digestive Diseases and Sciences was to estimate gender-based differences in a unique population-based cohort of patients with celiac disease with respect to presenting symptoms, associated autoimmune disorders, and survival. In this study, clinical data were systematically abstracted from the electronic medical record of a population-based incident cohort of patients with celiac disease. This study included 282 patients diagnosed between 1990 and 2015, of which 65% were females. It was found that men and women exhibited similar presentations. Women were more likely to present with constipation. Further, anemia and abdominal distention or bloating were more frequently seen in women, but not on a statistically significant level. On the other hand, autoimmune diseases were equally prevalent in males and females. Additionally, hypothyroidism predominated in women and age-adjusted survival was lower among men than women. Meanwhile, cancer was the most common cause of death, and there were two possible celiac disease-related deaths. From the findings, it was concluded that men and women are more alike than different with respect to celiac disease presentation and prevalence of concurrent autoimmune disease.5

1. Jansson-Knodell C, King K, Larson J, Van Dyke C, Murray J, Rubio-Tapia A. Gender-Based Differences in a Population-Based Cohort with Celiac Disease: More Alike than Unalike. Digestive Diseases and Sciences. 2017. doi:10.1007/s10620-017-4835-0.